Lipid droplets are dynamic intracellular lipid storage organelles that respond to the
physiological state of cells. In addition to controlling cell metabolism, they play a protective …

Metabolic disorders, particularly aberrations in lipid homeostasis, such as obesity, type 2
diabetes mellitus, and hypertriglyceridemia often manifest together as the metabolic …

Dysregulation of cholesterol homeostasis in the brain is increasingly being linked to chronic
neurodegenerative disorders, including Alzheimer's disease (AD), Huntington's disease …

The APOE4 protein affects the primary neuropathological markers of Alzheimer's disease
(AD): amyloid plaques, neurofibrillary tangles, and gliosis. These interactions have been …

▪ Abstract The low-density lipoprotein receptor (LDLR) is responsible for uptake of
cholesterol-carrying lipoprotein particles into cells. The receptor binds lipoprotein particles at …

The promise of precision medicine lies in data diversity. More than the sheer size of
biomedical data, it is the layering of multiple data modalities, offering complementary …

VPS10P-domain receptors, such as SORLA and sortilin, constitute a recently identified class
of type-1 receptors that are expressed in neurons. Family members are multifunctional …

The brain is the most lipid-rich organ in the body and, owing to the impermeable nature of
the blood–brain barrier, lipid and lipoprotein metabolism within this organ is distinct from the …

The E4 allele of the ApoE gene has consistently been shown to be related to an increased
risk of Alzheimer's disease (AD). The E4 allele is also associated with functional and …

The LDL receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor that is
highly expressed on neurons. Neuronal LRP1 in vitro can mediate ligand endocytosis, as …