LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior
and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from …

During the past few years, new methods have evolved that allow much more accurate
measurements in vivo of the rate constants for the physiological processes that determine …

Dietary fatty acids have a considerable effect on plasma LDL cholesterol (LDL-C)
concentrations and therefore on the risk for coronary heart disease. Numerous studies have …

The cholesterol-lowering effects of tangerine peel extract and a mixture of two citrus
flavonoids were tested. Male rats were fed a 1 g/100 g high-cholesterol diet for 42 d with …

Due to its presumed role in regulating cellular cholesterol homeostasis, and in various
pathophysiological conditions, acyl-coenzyme A: cholesterol acyltransferase (ACAT) has …

Dietary polyphenols have been shown to possess cardioprotective effects. For example, the
most noted role of grape polyphenols is in the French Paradox, in which a diet high in …

The ileal apical sodium bile acid cotransporter participates in the enterohepatic circulation of
bile acids. In patients with primary bile acid malabsorption, mutations in the ileal bile acid …

The enzyme acyl coenzyme A: cholesterol acyltransferase 1 (ACAT1) mediates sterol
esterification, a crucial component of intracellular lipid homeostasis. Two enzymes catalyze …

Increased levels of IDL and small, dense LDL are associated with the risk of coronary artery
disease. Possible mechanisms include increased susceptibility of small, dense LDL to …

The present study demonstrates that two different forms of the intracellular cholesterol
esterification enzyme acyl-CoA: cholesterol acyltransferase (ACAT) are present in the …