Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino
acid is:(i) A main precursor of extracellular collagens (the most abundant human proteins) …

The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with
low treatment efficacy. However, the field is dominated by underpowered studies focusing …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

Introduction The main objective was to carry out a global DNA methylation analysis in a
population with gender incongruence before gender-affirming hormone treatment (GAHT), in …

The neutral amino acid transporter subfamily that consists of six members, consecutively
SLC6A15–SLC620, also called orphan transporters, represents membrane, sodium …

Metabolic homeostasis is maintained by redundant pathways to ensure adequate nutrient
supply during fasting and other stresses. These pathways are regulated locally in tissues …

NMDA-type glutamate receptors (NMDARs) constitute one of the main glutamate (Glu)
targets in the central nervous system and are involved in synaptic plasticity, which is the …

The pharmacology of amino acid transporters in the SLC6 family is poorly developed
compared to that of the neurotransmitter transporters. To identify new inhibitors of the proline …

Proline is widely known as the only proteogenic amino acid with a secondary amine. In
addition to its crucial role in protein structure, the secondary amino acid modulates …