Dietary astaxanthin: an excellent carotenoid with multiple health benefits

Y Cao, L Yang, X Qiao, C Xue, J Xu - Critical Reviews in Food …, 2023 - Taylor & Francis
Astaxanthin is a carotenoid widely found in marine organisms and microorganisms. With
extensive use in nutraceuticals, cosmetics, and animal feed, astaxanthin will have the …

Transcription factor NRF2 as a promising therapeutic target for Alzheimer's disease

Z Qu, J Sun, W Zhang, J Yu, C Zhuang - Free Radical Biology and …, 2020 - Elsevier
Oxidative stress is considered as one of the pathogenesis of Alzheimer's disease (AD) and
plays an important role in the occurrence and development of AD. Nuclear factor erythroid 2 …

Nanotechnology-abetted astaxanthin formulations in multimodel therapeutic and biomedical applications

Z Jafari, A Bigham, S Sadeghi… - Journal of Medicinal …, 2021 - ACS Publications
Astaxanthin (AXT) is one of the most important fat-soluble carotenoids that have abundant
and diverse therapeutic applications namely in liver disease, cardiovascular disease, cancer …

The novel function of bexarotene for neurological diseases

Y Liu, P Wang, G Jin, P Shi, Y Zhao, J Guo, Y Yin… - Ageing Research …, 2023 - Elsevier
Bexarotene, a retinoid X receptor (RXR) agonist, is approved by FDA to treat cutaneous T-
cell lymphoma. However, it has also demonstrated promising therapeutic potential for …

Nose to brain delivery of astaxanthin–loaded nanostructured lipid carriers in rat model of Alzheimer's disease: Preparation, in vitro and in vivo evaluation

MK Shehata, AA Ismail, MA Kamel - International Journal of …, 2023 - Taylor & Francis
Background Astaxanthin (AST) is a second-generation antioxidant with anti-inflammatory
and neuroprotective properties and could be a promising candidate for Alzheimer's disease …

[HTML][HTML] Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer's disease-related blood brain …

JA Babalola, M Lang, M George, A Stracke… - Brain Research, 2023 - Elsevier
Defective degradation and clearance of amyloid-β as well as inflammation per se are crucial
players in the pathology of Alzheimer's disease (AD). A defective transport across the blood …

Recent advancements and future perspectives of microalgae-derived pharmaceuticals

D Xia, W Qiu, X Wang, J Liu - Marine drugs, 2021 - mdpi.com
Microalgal cells serve as solar-powered factories that produce pharmaceuticals,
recombinant proteins (vaccines and drugs), and valuable natural byproducts that possess …

Therapeutic potential of ADAM10 modulation in Alzheimer's disease: a review of the current evidence

MR Khezri, M Mohebalizadeh… - Cell Communication and …, 2023 - Springer
Abstract Alzheimer's disease (AD), the most common neurodegenerative disease
worldwide, is caused by loss of neurons and synapses in central nervous system. Several …

Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease

Y Pu, CK Cheng, H Zhang, JY Luo… - Medicinal Research …, 2023 - Wiley Online Library
The prevalence of cardiovascular disease (CVD) has been rising due to sedentary lifestyles
and unhealthy dietary patterns. Peroxisome proliferator‐activated receptor α (PPARα) is a …

Combined donepezil with astaxanthin via nanostructured lipid carriers effective delivery to brain for Alzheimer's disease in rat model

MK Shehata, AA Ismail, MA Kamel - International Journal of …, 2023 - Taylor & Francis
Introduction Donepezil (DPL), a specific acetylcholinesterase inhibitor, is used as a first-line
treatment to improve cognitive deficits in Alzheimer's disease (AD) and it might have a …