Osteoporosis has been defined as the silent disease of the 21st century, becoming a public
health risk due to its severity, chronicity and progression and affecting mainly …

The beneficial effects of physical activity (PA) are well documented, yet the mechanisms by
which PA prevents disease and improves health outcomes are poorly understood. To …

Abstract Background The Italian Society for Orthopaedics and Traumatology conceived this
guidance—which is primarily addressed to Italian orthopedic surgeons, but should also …

Primary biliary cirrhosis (PBC) is an autoimmune, slowly progressive, cholestatic, liver
disease characterized by a triad of chronic cholestasis, circulating anti-mitochondrial …

Osteoporosis is a chronical, systemic skeletal disorder characterized by an increase in bone
resorption, which leads to reduced bone density. The reduction in bone mineral density and …

Cancer treatments can damage the ovaries, causing primary ovarian insufficiency (POI), a
condition associated with numerous sequelae that impact long-term quality of life. This …

Purpose Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe but
extremely rare complication of prolonged treatment with bisphosphonates (BPs). Improper …

Abstract Dehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA) and its sulfated
metabolite DHEA-S are the most abundant steroids in circulation and decline with age …

Rheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-
immune diseases. The imbalance between helper (Th17) and regulatory T cells (Tregs) …

Highlights•Diet represents a crucial factor for the prevention of chronic-degenerative
diseases.•MetS and neurodegeneration are correlated to animal-derived product …