Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization …
BA Ference, W Yoo, I Alesh, N Mahajan… - Journal of the American …, 2012 - jacc.org
Objectives: The purpose of this study was to estimate the effect of long-term exposure to
lower plasma low-density lipoprotein cholesterol (LDL-C) on the risk of coronary heart …
lower plasma low-density lipoprotein cholesterol (LDL-C) on the risk of coronary heart …
Regulation of glucose and lipid metabolism in health and disease
Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …
most abundant sterol in mammals, is a key component of cell membranes although it does …
Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power
Admixed populations are routinely excluded from genomic studies due to concerns over
population structure. Here, we present a statistical framework and software package, Tractor …
population structure. Here, we present a statistical framework and software package, Tractor …
[HTML][HTML] The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions
Here, we introduce the 3D Genome Browser, http://3dgenome. org, which allows users to
conveniently explore both their own and over 300 publicly available chromatin interaction …
conveniently explore both their own and over 300 publicly available chromatin interaction …
Common variants at 30 loci contribute to polygenic dyslipidemia
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …
Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype
GC Barnett, CML West, AM Dunning, RM Elliott… - Nature Reviews …, 2009 - nature.com
A key challenge in radiotherapy is to maximize radiation doses to cancer cells while
minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients …
minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients …
Genotype imputation
Genotype imputation is now an essential tool in the analysis of genome-wide association
scans. This technique allows geneticists to accurately evaluate the evidence for association …
scans. This technique allows geneticists to accurately evaluate the evidence for association …
[HTML][HTML] Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Recent genome-wide association (GWA) studies of lipids have been conducted in samples
ascertained for other phenotypes, particularly diabetes. Here we report the first GWA …
ascertained for other phenotypes, particularly diabetes. Here we report the first GWA …
[HTML][HTML] The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome
Background Cardiovascular diseases and their associated risk factors remain the main
cause of mortality in western societies. In order to assess the prevalence of cardiovascular …
cause of mortality in western societies. In order to assess the prevalence of cardiovascular …
Plasma lipoproteins: genetic influences and clinical implications
RA Hegele - Nature Reviews Genetics, 2009 - nature.com
Susceptibility to the growing global public health problem of cardiovascular disease is
associated with levels of plasma lipids and lipoproteins. Several experimental strategies …
associated with levels of plasma lipids and lipoproteins. Several experimental strategies …