Blood homocysteine levels in children with autism spectrum disorder: An updated systematic review and meta-analysis

BQ Guo, HB Li, SB Ding - Psychiatry Research, 2020 - Elsevier
Results of studies on peripheral blood levels of homocysteine (Hcy) in children with autism
spectrum disorder (ASD) are inconsistent, and conclusions from two previous meta-analyses …

Diagnostic and severity-tracking biomarkers for autism spectrum disorder

G Bjørklund, NA Meguid, A El-Ansary… - Journal of Molecular …, 2018 - Springer
Autism spectrum disorder (ASD) is a neurodevelopmental disorder afflicting about one in
every 68 children. It is behaviorally diagnosed based on a triad of symptoms, including …

Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers

AM Khemakhem, RE Frye, A El-Ansary… - Metabolic brain …, 2017 - Springer
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is behaviorally
defined by social and communication impairments and restricted interests and repetitive …

The influence of choline treatment on behavioral and neurochemical autistic-like phenotype in Mthfr-deficient mice

G Agam, Z Taylor, E Vainer, HM Golan - Translational psychiatry, 2020 - nature.com
Imbalanced one carbon metabolism and aberrant autophagy is robustly reported in patients
with autism. Polymorphism in the gene methylenetetrahydrofolate reductase (Mthfr) …

Sulfur amino acid metabolism and related metabotypes of autism spectrum disorder: A review of biochemical evidence for a hypothesis

NLR Indika, NEP Deutz, MPKJ Engelen, H Peiris… - Biochimie, 2021 - Elsevier
There are multiple lines of evidence for an impaired sulfur amino acid (SAA) metabolism in
autism spectrum disorder (ASD). For instance, the concentrations of methionine, cysteine …

On the use of multivariate methods for analysis of data from biological networks

T Vargason, DP Howsmon, DL McGuinness, J Hahn - Processes, 2017 - mdpi.com
Data analysis used for biomedical research, particularly analysis involving metabolic or
signaling pathways, is often based upon univariate statistical analysis. One common …

Role of lncRNAs as prognostic markers of hepatic cancer and potential therapeutic targeting by S-adenosylmethionine via inhibiting PI3K/Akt signaling pathways

KM Sadek, MA Lebda, NE Nasr, SM Nasr… - … Science and Pollution …, 2018 - Springer
Hepatic cancer (HCC) is a well-identified dilemma throughout the world, and hence, the
molecular mechanisms and strategy for preventive protection against this malignancy are …

Comparison of three clinical trial treatments for autism spectrum disorder through multivariate analysis of changes in metabolic profiles and adaptive behavior

T Vargason, U Kruger, E Roth, LM Delhey… - Frontiers in cellular …, 2018 - frontiersin.org
Several studies associate autism spectrum disorder (ASD) pathophysiology with metabolic
abnormalities related to DNA methylation and intracellular redox homeostasis. In this regard …

Prenatal Nutritional Intervention Reduces Autistic-Like Behavior Rates Among Mthfr-Deficient Mice

A Orenbuch, K Fortis, S Taesuwan, R Yaffe… - Frontiers in …, 2019 - frontiersin.org
The causes and contributing factors of autism spectrum disorders (ASD) are poorly
understood. One gene associated with increased risk for ASD is methylenetetrahydrofolate …

The key role of purine metabolism in the folate-dependent phenotype of autism spectrum disorders: an in silico analysis

J Geryk, D Krsička, M Vlčková, M Havlovicová… - Metabolites, 2020 - mdpi.com
Folate deficiency in the critical developmental period has been repeatedly associated with
an increased risk of Autism spectrum disorders (ASD), but the key pathophysiological …