The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

Cancer cells selectively promote translation of specific oncogenic transcripts to facilitate
cancer survival and progression, but the underlying mechanisms are poorly understood …

Although hepatocellular carcinoma (HCC) is one of the deadliest health burdens worldwide,
few drugs are available for its clinical treatment. However, in recent years, major …

Metabolic reprogramming is a hallmark of cancer and allows tumour cells to meet the
increased energy demands required for rapid proliferation, invasion, and metastasis …

Gut dysbiosis is commonly observed in patients with cirrhosis and chronic gastrointestinal
disorders; however, its effect on antitumor immunity in the liver is largely unknown. Here we …

Accurate noninvasive tests (NITs) are needed to replace liver biopsy for identifying
advanced fibrosis caused by nonalcoholic steatohepatitis (NASH). We analyzed screening …

Abstract Background and Aims We previously demonstrated that cancer‐associated
fibroblasts (CAFs) promote tumor growth through recruitment of myeloid‐derived suppressor …

The transcriptional co-regulators YAP and TAZ pair primarily with the TEAD family of
transcription factors to elicit a gene expression signature that plays a prominent role in …