Revealing neuronal function through microelectrode array recordings

MEJ Obien, K Deligkaris, T Bullmann… - Frontiers in …, 2015 - frontiersin.org
Microelectrode arrays and microprobes have been widely utilized to measure neuronal
activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate …

[HTML][HTML] The technology, opportunities and challenges of synthetic biological intelligence

BJ Kagan, C Gyngell, T Lysaght, VM Cole… - Biotechnology …, 2023 - Elsevier
Integrating neural cultures developed through synthetic biology methods with digital
computing has enabled the early development of Synthetic Biological Intelligence (SBI) …

CMOS nanoelectrode array for all-electrical intracellular electrophysiological imaging

J Abbott, T Ye, L Qin, M Jorgolli, RS Gertner… - Nature …, 2017 - nature.com
Developing a new tool capable of high-precision electrophysiological recording of a large
network of electrogenic cells has long been an outstanding challenge in neurobiology and …

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

J Müller, M Ballini, P Livi, Y Chen, M Radivojevic… - Lab on a Chip, 2015 - pubs.rsc.org
Studies on information processing and learning properties of neuronal networks would
benefit from simultaneous and parallel access to the activity of a large fraction of all neurons …

In Vitro Multi-Functional Microelectrode Array Featuring 59 760 Electrodes, 2048 Electrophysiology Channels, Stimulation, Impedance Measurement, and …

J Dragas, V Viswam, A Shadmani… - IEEE journal of solid …, 2017 - ieeexplore.ieee.org
Biological cells are characterized by highly complex phenomena and processes that are, to
a great extent, interdependent. To gain detailed insights, devices designed to study cellular …

A fully integrated 8-channel closed-loop neural-prosthetic CMOS SoC for real-time epileptic seizure control

WM Chen, H Chiueh, TJ Chen, CL Ho… - IEEE journal of solid …, 2013 - ieeexplore.ieee.org
An 8-channel closed-loop neural-prosthetic SoC is presented for real-time intracranial EEG
(iEEG) acquisition, seizure detection, and electrical stimulation in order to suppress epileptic …

A 1024-channel CMOS microelectrode array with 26,400 electrodes for recording and stimulation of electrogenic cells in vitro

M Ballini, J Müller, P Livi, Y Chen, U Frey… - IEEE journal of solid …, 2014 - ieeexplore.ieee.org
To advance our understanding of the functioning of neuronal ensembles, systems are
needed to enable simultaneous recording from a large number of individual neurons at high …

CMOS electrochemical instrumentation for biosensor microsystems: A review

H Li, X Liu, L Li, X Mu, R Genov, AJ Mason - Sensors, 2016 - mdpi.com
Modern biosensors play a critical role in healthcare and have a quickly growing commercial
market. Compared to traditional optical-based sensing, electrochemical biosensors are …

Nernst limit in dual-gated Si-nanowire FET sensors

O Knopfmacher, A Tarasov, W Fu, M Wipf, B Niesen… - Nano …, 2010 - ACS Publications
Field effect transistors (FETs) are widely used for the label-free detection of analytes in
chemical and biological experiments. Here we demonstrate that the apparent sensitivity of a …

CMOS electrochemical pH localizer-imager

HS Jung, WB Jung, J Wang, J Abbott, A Horgan… - Science …, 2022 - science.org
pH controls a large repertoire of chemical and biochemical processes in water. Densely
arrayed pH microenvironments would parallelize these processes, enabling their high …