The adrenal cortex is divided into concentric zones. In humans the major cortical zones are
the zona glomerulosa, zona fasciculata, and zona reticularis. The adrenal cortex is a …

Refractory nephrotic syndrome continues to be a therapeutic challenge despite advances in
immunosuppression and blockade of the renin–angiotensin–aldosterone cascade …

The adrenal gland controls a plethora of crucial physiological functions, and dysfunction is
associated with severe morbidity. Because of the vital importance of appropriate adrenal …

Despite a critical role for MYC as an effector of oncogenic RAS, strategies to target MYC
activity in RAS-driven cancers are lacking. In genetically engineered mouse models of lung …

The adrenal cortex is characterized by three histologically and functionally distinct zones:
the outermost zona glomerulosa (zG), the intermediate zona fasciculata, and the innermost …

Signaling through fibroblast growth factor receptor one (FGFR1) is a known inducer of
proliferation in both embryonic and human adult mesenchymal stem cells (hMSCs) and …

Epidemiological evidence implicates excess adipose tissue in increasing cancer risk.
Despite a steeply rising global prevalence of obesity, how adiposity contributes to …

Developmental signalling pathways are implicated in the formation and maintenance of the
adrenal gland, but their roles are currently not well defined. In recent years it has emerged …

Context: Primary pigmented nodular adrenocortical disease, associated with Carney
complex, is caused by mutations in PRKAR1A (mt-PRKAR1A), a gene that codes for the …

Metadherin (MTDH) is a multifunctional oncogene involved in tumor cell migration and
metastasis through regulating a number of oncogenic signaling pathways in various human …