Tumors of glial origin consist of a core mass and a penumbra of invasive, single cells,
decreasing in numbers towards the periphery and still detectable several centimeters away …

Microglia, which contribute substantially to the tumor mass of glioblastoma, have been
shown to play an important role in glioma growth and invasion. While a large number of …

Abstract INVADING GLIOMA CELLS seem to follow distinct anatomic structures within the
central nervous system. Tumor cell dissemination may occur along structures, such as the …

Astrocytomas often show high rates of local invasion that lead to local recurrence of the
disease. Histologically, the most highly invasive astrocytoma cells are detected in isolation …

BACKGROUND Prostate tumors express high levels of transforming growth factor‐β1 (TGF‐
β1) and seem to acquire resistance to its antiproliferative effects with tumor progression …

Malignant brain tumors and brain metastases are highly aggressive diseases that are often
resistant to treatments. Consequently, the current prognosis of patients with brain tumors …

Members of the metzincin family of metalloproteinases have long been considered merely
degradative enzymes for extracellular matrix molecules. Recently, however, there has been …

Matrix metalloproteinases (MMPs) are a family of extracellular endopeptidases that
selectively degrade components of the extracellular matrix. MMPs are implicated in tumor …

Characteristics of human malignant glioma are excessive proliferation, infiltrative growth,
angiogenesis and suppression of anti‐tumor immune surveillance. Transforming growth …

It has become well accepted that solid tumors must create a vascular system for nutrient
delivery and waste removal in order to grow appreciably. This process, angiogenesis, is …