Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …

In the present perspective, we give a critical review on the coordination chemistry of the
metal ions copper and zinc to the amyloid-β (Aβ) peptide; such complexes have been linked …

Copper (Cu) is essential for living organisms, and acts as a cofactor in many metabolic
enzymes. To avoid the toxicity of free Cu, organisms have specific transport systems that …

Metals are essential elements of all living organisms. Among them, copper is required for a
multiplicity of functions including mitochondrial oxidative phosphorylation and protection …

Redox control in the mitochondrion is essential for the proper functioning of this organelle.
Disruption of mitochondrial redox processes contributes to a host of human disorders …

Copper is an essential but potentially harmful trace element required in many enzymatic
processes involving redox chemistry. Cellular copper homeostasis in mammals is …

The human protein Cox17 contains three pairs of cysteines. In the mitochondrial
intermembrane space (IMS) it exists in a partially oxidized form with two S–S bonds and two …

Copper chaperones compose a specific class of proteins assuring safe handling and
specific delivery of potentially harmful copper ions to a variety of essential copper proteins …

Diverse metal ions participate in multiple roles in protein structure and function. In addition to
their role in catalysis, electron transfer, and ligand binding, metal ions are important for the …

99% of all mitochondrial proteins are synthesized in the cytosol, from where they are
imported into mitochondria. In contrast to matrix proteins, many proteins of the …