Specialized pro-resolving mediator network: an update on production and actions

N Chiang, CN Serhan - Essays in Biochemistry, 2020 - portlandpress.com
Today, persistent and uncontrolled inflammation is appreciated to play a pivotal role in many
diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic …

[HTML][HTML] Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

CN Serhan - The FASEB Journal, 2017 - ncbi.nlm.nih.gov
Practitioners of ancient societies from the time of Hippocrates and earlier recognized and
treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or …

Identification and structure elucidation of the pro‐resolving mediators provides novel leads for resolution pharmacology

J Dalli, CN Serhan - British journal of pharmacology, 2019 - Wiley Online Library
Inflammatory diseases are a major socio‐economic burden, with the incidence of such
conditions on the rise, especially in western societies. For decades, the primary treatment …

Resolution of chronic inflammation and cancer

G Tezcan, N Yakar, H Hasturk, TE Van Dyke… - Periodontology …, 2024 - Wiley Online Library
Chronic inflammation poses challenges to effective cancer treatment. Although anti‐
inflammatory therapies have shown short‐term benefits, their long‐term implications may be …

Roles of resolvins in chronic inflammatory response

C Liu, D Fan, Q Lei, A Lu, X He - International journal of molecular …, 2022 - mdpi.com
An inflammatory response is beneficial to the organism, while an excessive uncontrolled
inflammatory response can lead to the nonspecific killing of tissue cells. Therefore …

Stereoselective semi‐hydrogenations of alkynes by first‐row (3d) transition metal catalysts

BJ Gregori, MOWS Schmotz… - …, 2022 - Wiley Online Library
The chemo‐and stereoselective semi‐hydrogenation of alkynes to alkenes is a fundamental
transformation in synthetic chemistry, for which the use of precious 4d or 5d metal catalysts …

Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid

A Vik, J Dalli, TV Hansen - Bioorganic & medicinal chemistry letters, 2017 - Elsevier
Several novel oxygenated polyunsaturated lipid mediators biosynthesized from n-3
docosapentaenoic acid were recently isolated from murine inflammatory exudates and …

Triacylglycerol‐rich oils of marine origin are optimal nutrients for induction of polyunsaturated docosahexaenoic acid ester of hydroxy linoleic acid (13‐DHAHLA) with …

V Paluchova, A Vik, T Cajka… - Molecular nutrition & …, 2020 - Wiley Online Library
Scope The docosahexaenoic acid ester of hydroxy linoleic acid (13‐DHAHLA) is a bioactive
lipid with anti‐inflammatory properties from the family of fatty acid esters of hydroxy fatty …

The eicosanoids, redox-regulated lipid mediators in immunometabolic disorders

AC Araújo, CE Wheelock… - Antioxidants & Redox …, 2018 - liebertpub.com
Significance: The oxidation of arachidonic acid via cyclooxygenase (COX) and lipoxygenase
(LOX) activity to produce eicosanoids during inflammation is a well-known biosynthetic …

[HTML][HTML] Role of polyunsaturated fatty acids in ischemic stroke–A perspective of specialized pro-resolving mediators

Z Miao, M Schultzberg, X Wang, Y Zhao - Clinical Nutrition, 2021 - Elsevier
Polyunsaturated fatty acids (PUFAs) have been proposed as beneficial for cardiovascular
health. However, results from both epidemiological studies and clinical trials have been …