Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain

G Ramesh, AG MacLean… - Mediators of inflammation, 2013 - Wiley Online Library
Cytokines and chemokines are proteins that coordinate the immune response throughout
the body. The dysregulation of cytokines and chemokines is a central feature in the …

Pathogenesis and pathophysiology of pneumococcal meningitis

BB Mook-Kanamori, M Geldhoff… - Clinical microbiology …, 2011 - Am Soc Microbiol
Pneumococcal meningitis continues to be associated with high rates of mortality and long-
term neurological sequelae. The most common route of infection starts by nasopharyngeal …

Cell death independent of caspases: a review

LE Broker, FAE Kruyt, G Giaccone - Clinical Cancer Research, 2005 - AACR
Patterns of cell death have been divided into apoptosis, which is actively executed by
specific proteases, the caspases, and accidental necrosis. However, there is now …

Role of microglia in central nervous system infections

RB Rock, G Gekker, S Hu, WS Sheng… - Clinical microbiology …, 2004 - Am Soc Microbiol
The nature of microglia fascinated many prominent researchers in the 19th and early 20th
centuries, and in a classic treatise in 1932, Pio del Rio-Hortega formulated a number of …

Role of AIF in caspase-dependent and caspase-independent cell death

SP Cregan, VL Dawson, RS Slack - Oncogene, 2004 - nature.com
The major challenge in treating cancer is that many tumor cells carry mutations in key
apoptotic genes such as p53, Bcl family proteins or those affecting caspase signaling. Such …

Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

C Candé, F Cecconi, P Dessen… - Journal of cell …, 2002 - journals.biologists.com
Numerous pro-apoptotic signal transducing molecules act on mitochondria and provoke the
permeabilization of the outer mitochondrial membrane, thereby triggering the release of …

Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling

SJ Hong, TM Dawson, VL Dawson - Trends in pharmacological sciences, 2004 - cell.com
Different cell-death mechanisms control many physiological and pathological processes in
humans. Mitochondria play important roles in cell death through the release of pro-apoptotic …

Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells

CH Choi, EY Lee, YC Lee, TI Park, HJ Kim… - Cellular …, 2005 - Wiley Online Library
Acinetobacter baumannii is an important opportunistic pathogen responsible for nosocomial
infection. Despite considerable clinical and epidemiological data regarding the role of A …

Pathogenesis and pathophysiology of pneumococcal meningitis

U Koedel, WM Scheld, HW Pfister - The Lancet infectious diseases, 2002 - thelancet.com
Until the introduction of antibiotics in the 1930s and 1940s, acute bacterial meningitis was
fatal in most cases. Since then it has become curable with a variable mortality and morbidity …

Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria

BM Polster, G Basanez, A Etxebarria… - Journal of Biological …, 2005 - ASBMB
The translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus has
been implicated in the mechanism of glutamate excitotoxicity in cortical neurons and has …