Thiol groups in protein cysteine (Cys) residues can undergo one-and two-electron oxidation
reactions leading to the formation of thiyl radicals or sulfenic acids, respectively. In this mini …

Ribonucleotide reductases (RNRs) are a diverse family of enzymes that are alone capable
of generating 2′-deoxynucleotides de novo and are thus critical in DNA biosynthesis and …

From the reduction of dinitrogen to the oxidation of water, the chemical transformations
catalysed by metalloenzymes underlie global geochemical and biochemical cycles. These …

Ribonucleotide reductases (RNRs) reduce ribonucleotides to deoxyribonucleotides using
radical-based chemistry. For class Ia RNRs, the radical species is stored in a separate …

Ribonucleotide reductases (RNRs) catalyze the reduction of ribonucleotides to
deoxyribonucleotides, thereby playing a key role in DNA replication and repair. Escherichia …

Ribonucleotide reductase (RNR) catalyzes the reduction of ribonucleotides to
deoxyribonucleotides and is critical for DNA synthesis and repair in all organisms. Its …

Ribonucleotide reductases (RNRs) catalyze the conversion of all four ribonucleotides to
deoxyribonucleotides and are essential for DNA synthesis in all organisms. The active form …

Ribonucleotide reductases (RNR) catalyze the reduction of nucleotides to deoxynucleotides
through a mechanism involving an essential cysteine based thiyl radical. In the E. coli class …

The Mo/W-bis PGD enzyme superfamily comprises a vast number of mononuclear
molybdenum and tungsten enzymes that catalyze a great diversity of vital reactions in …

The class Ia ribonucleotide reductase of Escherichia coli requires strict regulation of long-
range radical transfer between two subunits, α and β, through a series of redox-active amino …