A generalized mechanism for hormetic dose responses is proposed that is based on the
redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of …

This article provides the first extensive documentation of mechanisms of hormetic
dose/concentration responses. The mechanisms selected were principally those mediated …

This article provides the first extensive documentation of the dose response features of pre-
and postconditioning. Pre-and postconditioning studies with rigorous study designs, using …

In Part I, hormetic doses of a variety of agents stimulated adaptive responses that
conditioned and protected cells against the subsequent toxicity resulting from a second …

Keap1/Nrf2 system plays a critical role on cellular protection by regulating many antioxidant
and detoxification enzyme genes through the antioxidant response element (ARE). Thus, it …

Many phytochemicals demonstrate nonmonotonic dose/concentration-response termed
biphasic dose-response and are considered to be hormetic compounds, ie, they induce …

Apoptosis, programmed cell death type I, is a critical part of neurodegeneration in cerebral
ischemia, Parkinson's, and Alzheimer's disease. Apoptosis begins with activation of pro …

Berberine (BBR) is a renowned natural compound that exhibits potent neuroprotective
activities. However, the cellular and molecular mechanisms are still unclear. Hormesis is an …

Reactive oxygen species (ROS) and oxidative stress are thought to play a central role in
potentiating macrophage activation, causing excessive inflammation, tissue damage, and …

Ulcerative colitis (UC) is a chronic inflammatory bowel disease involving mainly the
colorectal mucosa and submucosa, the incidence of which has been on the rise in recent …