Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …

Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct
processes. Although our present understanding is incomplete and there are still great …

Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary financial and emotional burdens. Studies of …

Despite advances towards understanding the molecular pathophysiology of the
neurodegenerative dementias, the mechanisms linking molecular changes to …

Glial cell line–derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in
the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and …

Active transport along the axon is crucial to the neuron. Motor-driven transport supplies the
distal synapse with newly synthesized proteins and lipids, and clears damaged or misfolded …

The endosome/lysosome pathway is disrupted early in the course of both Alzheimer's
disease (AD) and Down syndrome (DS); however, it is not clear how dysfunction in this …

Multivesicular bodies (MVBs) are intracellular endosomal organelles characterized by
multiple internal vesicles that are enclosed within a single outer membrane. MVBs were …

Neuronal arborization is regulated by cell-autonomous and nonautonomous mechanisms
including endosomal signaling via BDNF/TrkB. The endosomal Na+/H+ exchanger 6 …

The intracellular trafficking machinery contributes to the spatial and temporal control of
signaling by receptor tyrosine kinases (RTKs). The primary role in this process is played by …