Neutrophil extracellular traps and long COVID

A Shafqat, MH Omer, I Albalkhi… - Frontiers in …, 2023 - frontiersin.org
Post-acute COVID-19 sequelae, commonly known as long COVID, encompasses a range of
systemic symptoms experienced by a significant number of COVID-19 survivors. The …

Tackling the glial scar in spinal cord regeneration: new discoveries and future directions

A Shafqat, I Albalkhi, HM Magableh, T Saleh… - Frontiers in cellular …, 2023 - frontiersin.org
Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified
by the formation of an injury scar. While this scar was traditionally believed to be primarily …

Senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment

D Maggiorani, O Le, V Lisi, S Landais… - Nature …, 2024 - nature.com
The potential of immune checkpoint inhibitors (ICI) may be limited in situations where
immune cell fitness is impaired. Here, we show that the efficacy of cancer immunotherapies …

RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment

Y Chen, J Wen, Q Li, D Peng, C Liao, X Ma, M Wang… - Leukemia, 2024 - nature.com
The fate of leukaemia stem cells (LSCs) is determined by both their inherent mechanisms
and crosstalk with their niches. Although LSCs were confirmed to be eradicated by restarting …

Cellular senescence in brain aging and cognitive decline

A Shafqat, S Khan, MH Omer, M Niaz… - Frontiers in aging …, 2023 - frontiersin.org
Cellular senescence is a biological aging hallmark that plays a key role in the development
of neurodegenerative diseases. Clinical trials are currently underway to evaluate the …

Lessons in aging from Myc knockout mouse models

EV Prochownik, H Wang - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Despite MYC being among the most intensively studied oncogenes, its role in normal
development has not been determined as Myc−/− mice do not survival beyond mid …

Nicotinamide riboside intervention alleviates hematopoietic system injury of ionizing radiation‐induced premature aging mice

W Li, X Wang, Y Dong, Q Huo, T Yue, X Wu, L Lu… - Aging cell, 2023 - Wiley Online Library
Radiotherapy destroys cancer cells and inevitably harms normal human tissues, causing
delayed effects of acute radiation exposure (DEARE) and accelerating the aging process in …

Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications

C Jazieh, TZ Arabi, Z Asim, BN Sabbah… - Frontiers in …, 2024 - frontiersin.org
Type 2 diabetes mellitus (T2DM) is a rapidly escalating global health concern, with its
prevalence projected to increase significantly in the near future. This review delves into the …

Why do patients with cancer die?

A Boire, K Burke, TR Cox, T Guise… - Nature Reviews …, 2024 - nature.com
Cancer is a major cause of global mortality, both in affluent countries and increasingly in
developing nations. Many patients with cancer experience reduced life expectancy and …

Computer simulation of molecular recognition in biomolecular system: from in silico screening to generalized ensembles

Y Fukunishi, J Higo, K Kasahara - Biophysical Reviews, 2022 - Springer
Prediction of ligand-receptor complex structure is important in both the basic science and the
industry such as drug discovery. We report various computation molecular docking methods …