Model-guided design of microRNA-based gene circuits supports precise dosage of transgenic cargoes into diverse primary cells
KS Love, CP Johnstone, EL Peterman, S Gaglione… - …, 2024 - pmc.ncbi.nlm.nih.gov
To realize the potential of engineered cells in therapeutic applications, transgenes must be
expressed within the window of therapeutic efficacy. Differences in copy number and other …
expressed within the window of therapeutic efficacy. Differences in copy number and other …
High-resolution profiling reveals coupled transcriptional and translational regulation of transgenes
EL Peterman, DS Ploessl, KS Love, V Sanabria… - bioRxiv, 2024 - biorxiv.org
Concentrations of RNAs and proteins provide important determinants of cell fate. Robust
gene circuit design requires an understanding of how the combined actions of individual …
gene circuit design requires an understanding of how the combined actions of individual …