The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first
described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and …

Polyphosphoinositides (PPIn) are an important family of phospholipids located on the
cytoplasmic leaflet of eukaryotic cell membranes. Collectively, they are critical for the …

Akt signaling plays a central role in many biological functions, such as cell proliferation and
apoptosis. Because Akt (also known as protein kinase B) resides primarily in the cytosol, it is …

The membranes of eukaryotic cells create hydrophobic barriers that control substance and
information exchange between the inside and outside of cells and between cellular …

Membrane rafts are thought to be sphingolipid-and cholesterol-dependent lateral
assemblies involved in diverse cellular functions. Their biological roles and even their …

Background Tks5 regulates invadopodium formation, but the precise timing during
invadopodium lifetime (initiation, stabilization, maturation) when Tks5 plays a role is not …

Summary p53 and Akt are critical players regulating tumorigenesis with opposite effects:
whereas p53 transactivates target genes to exert its function as a tumor suppressor, Akt …

ARNO is a soluble guanine nucleotide exchange factor (GEF) for the Arf family of GTPases.
Although in biochemical assays ARNO prefers Arf1 over Arf6 as a substrate, its localization …

Akt (also known as PKB) signaling orchestrates many aspects of biological functions and,
importantly, its deregulation is linked to cancer development. Akt activity is well-known …

The PI3-kinase (PI3K) pathway regulates many cellular processes, especially cell
metabolism, cell survival, and apoptosis. Phosphatidylinositol-3, 4, 5-trisphosphate (PIP3) …