Glioblastoma multiforme, diagnosis and treatment; recent literature review

R Batash, N Asna, P Schaffer, N Francis… - Current medicinal …, 2017 - ingentaconnect.com
Background: Glioblastoma multiforme (GBM) is the most common malignant primary brain
tumor, with an incidence of 3.19 cases per 100,000 person years and remarkably poor …

Harnessing the immune system in glioblastoma

NF Brown, TJ Carter, D Ottaviani… - British journal of cancer, 2018 - nature.com
Glioblastoma is the most common primary malignant brain tumour. Survival is poor and
improved treatment options are urgently needed. Although immunotherapies have emerged …

PD-L1/PD-1 axis in glioblastoma multiforme

J Litak, M Mazurek, C Grochowski, P Kamieniak… - International journal of …, 2019 - mdpi.com
Glioblastoma (GBM) is the most popular primary central nervous system cancer and has an
extremely expansive course. Aggressive tumor growth correlates with short median overall …

Immune evasion strategies of glioblastoma

SM Razavi, KE Lee, BE Jin, PS Aujla, S Gholamin… - Frontiers in …, 2016 - frontiersin.org
Glioblastoma (GBM) is the most devastating brain tumor, with associated poor prognosis.
Despite advances in surgery and chemoradiation, the survival of afflicted patients has not …

Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma

Y Xun, H Yang, B Kaminska, H You - Journal of hematology & oncology, 2021 - Springer
Glioma represents a fast proliferating and highly invasive brain tumor which is resistant to
current therapies and invariably recurs. Despite some advancements in anti-glioma …

Biomarkers and therapeutic advances in glioblastoma multiforme

AO Sasmita, YP Wong, APK Ling - Asia‐Pacific Journal of …, 2018 - Wiley Online Library
Glioblastoma multiforme (GBM) is a malignant tumor within the brain. Generally classified as
primary and secondary with several different subtypes, ample molecular biomarkers have …

Drug and gene delivery across the blood–brain barrier with focused ultrasound

KF Timbie, BP Mead, RJ Price - Journal of Controlled Release, 2015 - Elsevier
The blood–brain barrier (BBB) remains one of the most significant limitations to treatments of
central nervous system (CNS) disorders including brain tumors, neurodegenerative …

Neutrophils in gliomas

M Massara, P Persico, O Bonavita… - Frontiers in …, 2017 - frontiersin.org
Neutrophils are the most abundant white blood cells and are the first recruited to
inflammatory sites. Neutrophils are an important component of the tumor stroma and can …

Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

DM Lussier, EC Woolf, JL Johnson, KS Brooks… - BMC cancer, 2016 - Springer
Background Glioblastoma multiforme is a highly aggressive brain tumor with a poor
prognosis, and advances in treatment have led to only marginal increases in overall …

Glycan modification of glioblastoma-derived extracellular vesicles enhances receptor-mediated targeting of dendritic cells

SA Dusoswa, SK Horrevorts, M Ambrosini… - Journal of …, 2019 - Taylor & Francis
Glioblastoma is the most prevalent and aggressive primary brain tumour for which total
tumour lysate-pulsed dendritic cell vaccination is currently under clinical evaluation …