SARS-CoV-2: from its discovery to genome structure, transcription, and replication

AC Brant, W Tian, V Majerciak, W Yang, ZM Zheng - Cell & bioscience, 2021 - Springer
SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia
COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single …

Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

E Shirbhate, J Pandey, VK Patel, M Kamal… - Pharmacological …, 2021 - Springer
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with
hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular …

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

Z Xu, JH Choi, DL Dai, J Luo… - Proceedings of the …, 2022 - National Acad Sciences
Viruses evade the innate immune response by suppressing the production or activity of
cytokines such as type I interferons (IFNs). Here we report the discovery of a mechanism by …

[HTML][HTML] RETRACTED: SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V (D) J Recombination In Vitro

H Jiang, YF Mei - Viruses, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus
disease 2019 (COVID–19) pandemic, severely affecting public health and the global …

SARS‐CoV‐2 papain‐like protease: structure, function and inhibition

S Ullrich, C Nitsche - Chembiochem, 2022 - Wiley Online Library
Emerging variants of SARS‐CoV‐2 and potential novel epidemic coronaviruses underline
the importance of investigating various viral proteins as potential drug targets. The papain …

SARS-CoV-2 non-structural proteins and their roles in host immune evasion

ZY Low, NZ Zabidi, AJW Yip, A Puniyamurti, VTK Chow… - Viruses, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) has caused an unprecedented global crisis and
continues to threaten public health. The etiological agent of this devastating pandemic …

CovInter: interaction data between coronavirus RNAs and host proteins

K Amahong, W Zhang, Y Zhou, S Zhang… - Nucleic Acids …, 2023 - academic.oup.com
Coronavirus has brought about three massive outbreaks in the past two decades. Each step
of its life cycle invariably depends on the interactions among virus and host molecules. The …

Off balance: Interferons in COVID-19 lung infections

MA Akamatsu, JT de Castro, CY Takano, PL Ho - EBioMedicine, 2021 - thelancet.com
Interferons are innate and adaptive cytokines involved in many biological responses, in
particular, viral infections. With the final response the result of the balance of the different …

Understanding the impact of the COVID-19 pandemic, lockdowns and social isolation on sleep quality

D O'regan, ML Jackson, AH Young… - Nature and science of …, 2021 - Taylor & Francis
The uncertain, ever-changing and an ongoing nature of the COVID-19 pandemic means that
it may take some time before we can fully appreciate the negative effect of the pandemic and …

[HTML][HTML] COVID-19 signalome: Pathways for SARS-CoV-2 infection and impact on COVID-19 associated comorbidity

K Lundstrom, A Hromić-Jahjefendić, E Bilajac… - Cellular …, 2023 - Elsevier
The COVID-19 pandemic has been the focus of research the past two years. The major
breakthrough was made by discovering pathways related to SARS-CoV-2 infection through …