Chromatin structure and gene expression are dynamically controlled by post-translational
modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

Double-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired,
may lead to genome instability or cell death. Here, we report that, in response to DSBs, the …

Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the
eukaryotic genome and a focal point for cellular regulation during development …

ABSTRACT Cyclin-dependent kinase 9 (CDK9) is critical for RNA Polymerase II (Pol II)
transcription initiation, elongation, and termination in several key biological processes …

Various cyclin-dependent kinase (Cdk) complexes have been implicated in the regulation of
transcription. In this study, we identified a 70-kDa Cyclin K (CycK) that binds Cdk12 and …

The C-terminal domain of RNA polymerase II's largest subunit undergoes dynamic
phosphorylation during transcription, and the different phosphorylation patterns that …

The positive transcription elongation factor b (P-TEFb) is a cyclin-dependent kinase that
controls the elongation phase of transcription by RNA polymerase II (RNAPII). This process …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …