Oligodendrocytes and the myelin they produce are a remarkable vertebrate specialization
that enables rapid and efficient nerve conduction within the central nervous system. The …

Given the complexities of the mammalian CNS, its regeneration is viewed as the holy grail of
regenerative medicine. Extraordinary efforts have been made to understand developmental …

A major challenge in understanding vertebrate embryogenesis is the lack of topographical
transcriptomic information that can help correlate microenvironmental cues within the …

Highlights•Secreted signals regulate OPC specification during development and in the
adult.•OL differentiation is controlled by chromatin remodeling and transcription …

The adult spinal cord stem cell potential resides within the ependymal cell population and
declines with age. Ependymal cells are, however, heterogeneous, and the biological …

Despite its importance in central nervous system development, development of the human
neural tube (NT) remains poorly understood, given the challenges of studying human …

The mechanisms of vertebrate Hedgehog signaling are linked to the biology of the primary
cilium, an antenna-like organelle that projects from the surface of most vertebrate cell types …

The adult mammalian spinal cord has limited regenerative capacity in settings such as
spinal cord injury (SCI) and multiple sclerosis (MS). Recent studies have revealed that …

Spinal cord injury results in the loss of neurons and axonal connections. In mammals,
including humans, this loss is permanent, but is repaired in other vertebrates, such as …

Neural-derived signals are crucial regulators of CNS vascularization. However, whether the
vasculature responds to these signals by means of elongating and branching or in addition …