Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

Cyclodextrin (CD), a cyclic oligosaccharide, is a pharmaceutical additive that improves the
solubility of hydrophobic compounds. Recent research has focused on the potential active …

Niemann-Pick type C1 (NPC) disease is a lysosomal storage disease caused by mutations
in the NPC1 gene, leading to an increase in unesterified cholesterol and several …

Antiretroviral therapy extends the lifespan of human immunodeficiency virus (HIV)-infected
patients, but many survivors develop premature impairments in cognition. These residual …

Current evidence indicates that excess brain cholesterol regulates amyloid-β (Aβ)
deposition, which in turn can regulate cholesterol homeostasis. Moreover, Aβ neurotoxicity …

Abstract Background Intrathecal 2-hydoxypropyl-β-cyclodextrin has been found to mobilize
cholesterol, extend life, reduce cerebellar pathology, and delay onset of ataxia in the mouse …

Introduction Alzheimer's disease (AD) is the most dominant neurodegenerative disorder that
causes dementia, and no effective treatments are available. To study its pathogenesis and …

Alzheimer's disease (AD) and Niemann–Pick type C (NPC) disease are progressive
neurodegenerative diseases with very different epidemiology and etiology. AD is a common …

This article reviews canine and feline brain aging. Several key features are discussed and
compared, including general aging characteristics and neuropathology. Aging dogs and …

Niemann-Pick type C disease (NPC) is a rare inherited neurodegenerative disorder
characterized by an accumulation of intracellular cholesterol within late endosomes and …