In pigs, the major histocompatibility complex (MHC), or swine leukocyte antigen (SLA)
complex, maps to Sus scrofa chromosome 7. It consists of three regions, the class I and …

The immune system plays dual roles in response to cancer. The host immune system
protects against tumor formation via immunosurveillance; however, recognition of the tumor …

Within the last decade there have been several severe combined immunodeficient (SCID)
pig models discovered or genetically engineered. The animals have mutations in ARTEMIS …

Pigs with severe combined immunodeficiency (SCID) are an emerging biomedical animal
model. Swine are anatomically and physiologically more similar to humans than mice …

Background Severe combined immunodeficient (SCID) pigs are an emerging animal model
being developed for biomedical and regenerative medicine research. SCID pigs can …

Severe combined immunodeficiency (SCID) is defined by the lack of an adaptive immune
system. Mutations causing SCID are found naturally in humans, mice, horses, dogs, and …

Artemis is a key nuclease involved in the non-homologous end joining repair pathway upon
DNA double-stranded breaks and during V (D) J recombination. It participates in various …

Genetic modification of genes such as recombination activating gene 2 (RAG2) or
interleukin-2 receptor-γ (IL2RG) results in pigs exhibiting severe combined …

The absence of clinically relevant large animal tumor models has historically forced
experimental cellular therapies for hematological malignancies to translate directly from …

Severe combined immunodeficiency (SCID) is described as the lack of functional T and B
cells. In some cases, mutant genes encoding proteins involved in the process of VDJ …