The distinct biochemical and antiviral mechanism of action of integrase strand transfer
inhibitors are directly relevant to understanding the clinical properties which are …

Antiretroviral therapy (ART) is typically composed of a combination of three antiretroviral
drugs and is the treatment of choice for people with human immunodeficiency virus type …

The ability of HIV to infect quiescent CD4+ T cells has been a topic of intense debate. While
early studies suggested that the virus could not infect this particular T cell subset …

HIV-1 can move directly between T cells via virological synapses (VS). Although aspects of
the molecular and cellular mechanisms underlying this mode of spread have been …

HIV infection has been associated with defective hematopoiesis since the earliest days of
the HIV/AIDS epidemic. Generation of all hematopoietic lineages suffers in the face of …

In vivo and in vitro exposure to stimulants has been associated with increased levels of HIV
infection in PBMCs. Among these lymphocyte subsets, quiescent CD4+ T cells make up the …

Epigenetic modifications refer to a number of biological processes which alter the structure
of chromatin and its transcriptional activity such as DNA methylation and histone post …

HIV-1 is taken up by immature monocyte derived dendritic cells (iMDDCs) into tetraspanin
rich caves from which the virus can either be transferred to T lymphocytes or enter into …

TLR2 activation plays a crucial role in Neisseria gonorrheae-mediated enhancement of HIV
infection of resting CD4+ T cells. We examined signaling pathways involved in the HIV …

Several studies have related epigenetic mechanisms to HIV-1 latency. However, the
epigenetic modifications of the host cell genome involved in the early stages of HIV-1 …