Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate
skeletal development. FGF signaling regulates development of the limb bud and formation of …

FGF signaling plays a ubiquitous role in human biology as a regulator of embryonic
development, homeostasis and regenerative processes. In addition, aberrant FGF signaling …

Sulfatases, which cleave sulfate esters in biological systems, play a key role in regulating
the sulfation states that determine the function of many physiological molecules. Sulfatase …

To mimic the high affinity of heparin-binding proteins to heparin/heparan sulfate, the uronic
acids in non-sulfated alginate were sulfated, and hydrogels of mixed alginate/alginate …

Phosphaturic mesenchymal tumors typically cause paraneoplastic osteomalacia, chiefly as
a result of FGF23 secretion. In a prior study, we identified FN1–FGFR1 fusion in 9 of 15 …

Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and variously implicated in …

Adhesion and migration are integrated cell functions that build, maintain and remodel the
multicellular organism. In migrating cells, integrins are the main transmembrane receptors …

Over the past decade, the glycosaminoglycans heparin and heparan sulfate have been
shown to bind and regulate the activities of many proteins. Established techniques have …