Food effects on gastrointestinal physiology and drug absorption
A Kambayashi, Y Shirasaka - Drug metabolism and pharmacokinetics, 2023 - Elsevier
Food ingestion affects the oral absorption of many drugs in humans. In this review article, we
summarize the physiological factors in the gastrointestinal (GI) tract that affect the in vivo …
summarize the physiological factors in the gastrointestinal (GI) tract that affect the in vivo …
[HTML][HTML] Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: history, methodology and applications
P Augustijns, M Vertzoni, C Reppas, P Langguth… - European Journal of …, 2020 - Elsevier
Fluid sampling from the gastrointestinal (GI) tract has been applied as a valuable tool to gain
more insight into the fluids present in the human GI tract and to explore the dynamic …
more insight into the fluids present in the human GI tract and to explore the dynamic …
Improving dissolution behavior and oral absorption of drugs with pH-dependent solubility using ph modifiers: a physiologically realistic mass transport analysis
Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed
through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's …
through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's …
Bridging the gap between food effects under clinical trial conditions and real life: modeling delayed gastric emptying of drug substances and gastric content volume …
F Winter, P Schick, W Weitschies - Molecular Pharmaceutics, 2022 - ACS Publications
Delayed gastric emptying is known to have a major impact on drug absorption. While the test
meal recommended by the FDA and EMA to study food effects represents a worst-case …
meal recommended by the FDA and EMA to study food effects represents a worst-case …
Best practices in the development and validation of physiologically based biopharmaceutics modeling. A workshop summary report
N Parrott, S Suarez-Sharp, F Kesisoglou… - Journal of …, 2021 - Elsevier
This workshop report summarizes the proceedings of Day 2 of a three-day workshop on
“Current State and Future Expectations of Translational Modeling Strategies to Support Drug …
“Current State and Future Expectations of Translational Modeling Strategies to Support Drug …
Toward developing discriminating dissolution methods for formulations containing nanoparticulates in solution: The impact of particle drift and drug activity in solution
Enabling formulations are an attractive approach to increase the dissolution rate, solubility,
and oral bioavailability of poorly soluble compounds. With the growing prevalence of poorly …
and oral bioavailability of poorly soluble compounds. With the growing prevalence of poorly …
The introduction of a new flexible in vivo predictive dissolution apparatus, GIS-alpha (GIS-α), to study dissolution profiles of BCS class IIb drugs, dipyridamole and …
Y Tsume, S Patel, M Wang, A Hermans… - Journal of …, 2020 - Elsevier
The physiological pH changes and peristalsis activities in gastrointestinal (GI) tract have big
impact on the dissolution of oral drug products, when those oral drug products include APIs …
impact on the dissolution of oral drug products, when those oral drug products include APIs …
Exploring the impact of real-life dosing conditions on intraluminal and systemic concentrations of atazanavir in parallel with gastric motility recording in healthy …
This work strived to explore gastrointestinal (GI) dissolution, supersaturation and
precipitation of the weakly basic drug atazanavir in humans under different 'real-life'intake …
precipitation of the weakly basic drug atazanavir in humans under different 'real-life'intake …
Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola® on the Luminal and Systemic Behavior of …
B Hens, M Bermejo, P Augustijns, R Cristofoletti… - Pharmaceutics, 2020 - mdpi.com
In the present work, we explored if Coca-Cola® had a beneficial impact on the systemic
outcome of the weakly basic drug loratadine (Wal-itin®, immediate-release formulation, 10 …
outcome of the weakly basic drug loratadine (Wal-itin®, immediate-release formulation, 10 …
Leveraging oral drug development to a next level: impact of the IMI-funded OrBiTo project on patient healthcare
B Hens, P Augustijns, H Lennernäs, M McAllister… - Frontiers in …, 2021 - frontiersin.org
A thorough understanding of the behavior of drug formulations in the human gastrointestinal
(GI) tract is essential when working in the field of oral drug development in a pharmaceutical …
(GI) tract is essential when working in the field of oral drug development in a pharmaceutical …