Ageing is a process that gradually increases the organism's vulnerability to death. It affects
different biological pathways, and the underlying cellular mechanisms are complex. In view …

The effects of healthy aging on the kidney, and how these effects intersect with
superimposed diseases, are highly relevant in the context of the population's increasing …

With an aging population, kidney health becomes an important medical and socioeconomic
factor. Kidney aging mechanisms are not well understood. We previously showed that …

Mice are an ideal mammalian model for studying the genetics of aging: considerable
resources are available, the generation time is short, and the environment can be easily …

Early diagnosis of diabetic nephropathy (DN) is difficult although it is of crucial importance to
prevent its development. To probe potential markers and the underlying mechanism of DN …

Even in healthy individuals, renal function gradually declines during aging. However, an
observed variation in the rate of this decline has raised the possibility of slowing or delaying …

Recent longitudinal studies in dietary daily intake in human centenarians have shown that a
satisfactory content of some micronutrients within the cells maintain several immune …

In ageing, alterations in inflammatory/immune response and antioxidant capacity lead to
increased susceptibility to diseases and loss of mobility and agility. Various essential …

Inbred mice provide a unique tool to study aging populations because of the genetic
homogeneity within an inbred strain, their short life span, and the tools for analysis which are …

The first clinical trial aimed at targeting fundamental processes of aging will soon be
launched (TAME: Targeting Aging with Metformin). In its wake is a robust pipeline of …