Antibiotic resistance is a major and increasing healthcare problem that threatens many of
the achievements of modern medicine. Transplants, chemotherapy, and survival of …

Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene,
and generally an acquired mechanism results in a predictable increase in phenotypic …

Infectious diseases caused by clinically important Mycobacteria continue to be an important
public health problem worldwide primarily due to emergence of drug resistance crisis. In …

For tuberculosis to be eradicated, the transmission of Multi-Drug-Resistant and eXtensively
Drug Resistant strains of Mycobacterium tuberculosis (MDR and XDR-TB) must be …

Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is the deadliest infectious
disease and the associated global threat has worsened with the emergence of drug …

Background: Whole-genome sequencing (WGS) is a viable and financially feasible tool for
timely and comprehensive diagnosis of drug resistance in developed countries. With the …

Bacterial persisters are a subpopulation of cells that can tolerate lethal concentrations of
antibiotics. However, the possibility of the emergence of genetically resistant mutants from …

Natural products provide a rich source of potential antimicrobials for treating infectious
diseases for which drug resistance has emerged. Foremost among these diseases is …

Offering patients with tuberculosis (TB) an optimal and timely treatment regimen depends on
the rapid detection of Mycobacterium tuberculosis (Mtb) drug resistance from clinical …

Antimicrobial resistance remains a persistent and pressing public health concern. Here, we
describe the synthesis of original triazole-containing inhibitors targeting the DNA gyrase, a …