Prostate cancer (PCa), a hormonally-driven cancer, ranks first in incidence and second in
cancer related mortality in men in most Western industrialized countries. Androgen and …

In the present minireview, we intend to provide a brief history of the field of CD9 involvement
in oncogenesis and in the metastatic process of cancer, considering its potential value as a …

We established a genome-wide compendium of somatic mutation events in 3949 whole
cancer genomes representing 19 tumor types. Protein-coding events captured well …

To facilitate intercellular communication, cells release nano-sized, extracellular vesicles
(EVs) to transfer biological cargo to both local and distant sites. EVs are enriched in …

Environmental exposure to phthalates during intrauterine development might increase
susceptibility to neoplasms in reproductive organs such as the prostate. Although studies …

Background Finding the tumor location in the prostate is an essential pathological step for
prostate cancer diagnosis and treatment. The location of the tumor–the laterality–can be …

Proliferation and maintenance of both normal and prostate cancer (PCa) cells is highly
regulated by steroid hormones, particularly androgens, and the extracellular environment …

Here we train cis-regulatory models of prostate tissue gene expression and impute
expression transcriptome-wide for 233,955 European ancestry men (14,616 prostate cancer …

Experimental studies on immunoglobulin superfamily (IgSF) member EWI2 reveal that it
suppresses a variety of solid malignant tumors including brain, lung, skin, and prostate …

Previous studies have demonstrated an involvement of chromatin-remodelling SWI/SNF
complexes in the development of prostate cancer, suggesting both tumor suppressor and …