Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

We present a review of the characterization of healthy brain aging using MRI with an
emphasis on morphology, lesions, and quantitative MR parameters. A scope review found …

Although multiple sclerosis has traditionally been considered a white matter disease,
extensive research documents the presence and importance of grey matter injury including …

Multiple sclerosis (MS) produces demyelination and degeneration in both gray and white
matter. Both cortical and deep gray matter injury is observed during the course of MS …

Increased brain iron concentration is often reported concurrently with disease development
in multiple sclerosis (MS) and other neurodegenerative diseases. However, it is unclear …

Objectives Conventional MRI is not sensitive to many pathological processes underpinning
multiple sclerosis (MS) ongoing in normal appearing brain tissue (NABT). Quantitative MRI …

The cerebellar nuclei are a brain region with high iron content. Surprisingly, little is known
about iron content in the cerebellar nuclei and its possible contribution to pathology in …

BACKGROUND AND PURPOSE: Modifications of magnetic susceptibility have been
consistently demonstrated in the subcortical gray matter of MS patients, but some …

Objectives The clinical impact of brain microstructural abnormalities in multiple sclerosis
(MS) remains elusive. We aimed to characterize the topography of longitudinal relaxation …

Despite robust postmortem evidence and potential clinical importance of gray matter (GM)
pathology in multiple sclerosis (MS), assessing GM damage by conventional magnetic …