[HTML][HTML] Late-onset epilepsy clinic: from clinical diagnostics to biomarkers

V Punia, S Bhansali, C Tsai - Seizure: European Journal of Epilepsy, 2024 - Elsevier
The unique patho-clinical entity of late-onset epilepsy (LOE), distinguished by its distinct
natural history, from its onset to the prognosis it portends, necessitates specialized care. We …

Tackling seizures in patients with Alzheimer's disease

M Tombini, M Boscarino… - Expert Review of …, 2023 - Taylor & Francis
Introduction In past years, a possible bidirectional link between epilepsy and Alzheimer's
disease (AD) has been proposed: if AD patients are more likely to develop epilepsy, people …

Late-onset temporal lobe epilepsy: insights from brain atrophy and Alzheimer's disease biomarkers

A Ballerini, N Biagioli, C Carbone, A Chiari, M Tondelli… - Brain, 2025 - academic.oup.com
Considering the growing age of the world population, the incidence of epilepsy in older
adults is expected to increase significantly. It has been suggested that late-onset temporal …

Sigma-1 receptor modulation by clemastine highlights its repurposing as neuroprotective agent against seizures and cognitive deficits in PTZ-kindled rats

GA Badawi, MM Shokr, SM Elshazly, HF Zaki… - European Journal of …, 2024 - Elsevier
Epilepsy is a neurological disorder characterized by recurrent spontaneous seizures
alongside other neurological comorbidities. Cognitive impairment is the most frequent …

Alzheimer's Disease and Epilepsy: Exploring Shared Pathways and Promising Biomarkers for Future Treatments

AC Kalyvas, M Dimitriou, P Ioannidis… - Journal of Clinical …, 2024 - mdpi.com
Background: Alzheimer's disease (AD) and epilepsy represent two complex neurological
disorders with distinct clinical manifestations, yet recent research has highlighted their …

Bursts of brain erosion: seizures and age-dependent neurological vulnerability

N Cresto, L Givalois, J Badaut, A Janvier… - Trends in Molecular …, 2024 - cell.com
Hypersynchronous and exaggerated neuronal firing, exemplified by epileptiform activity and
seizures, are disruptors of brain function across acute and chronic neuropathological …

[HTML][HTML] A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity

G Bonifazi, C Luchena, A Gaminde-Blasco… - Neurobiology of …, 2024 - Elsevier
The pathophysiological process of Alzheimer's disease (AD) is believed to begin many
years before the formal diagnosis of AD dementia. This protracted preclinical phase offers a …

The association of seizure control with neuropathology in dementia

I Zawar, A Luniewski, R Gundlapalli, C Manning… - Brain, 2025 - academic.oup.com
Seizures in people with dementia (PWD) are associated with faster cognitive decline and
worse clinical outcomes. However, the relationship between ongoing seizure activity and …

The prevalence of chronic traumatic encephalopathy in a historical epilepsy post‐mortem collection

M Ryniejska, H El‐Hachami, A Mrzyglod, J Liu… - Brain …, 2024 - Wiley Online Library
Previous post‐mortem epilepsy series showed phosphorylated tau (pTau) accumulation in
relation to traumatic brain injury (TBI) rather than driven by seizure frequency. The Corsellis …

A Strategy for Allowing Earlier Diagnosis and Rigorous Evaluation of BACE1 Inhibitors in Preclinical Alzheimer's Disease

M Ohno - Journal of Alzheimer's Disease, 2024 - content.iospress.com
Given continued failure of BACE1 inhibitor programs at symptomatic and prodromal stages
of Alzheimer's disease (AD), clinical trials need to target the earlier preclinical stage …