Locally resident intraepithelial lymphocytes (IELs) are primarily T cells with potent cytolytic
and immunoregulatory capacities, which they use to sustain epithelial integrity. Here, we …

The intestinal mucosa represents the largest body surface toward the external environment
and harbors numerous T lymphocytes that take up resident within the intestinal epithelium or …

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a common but
poorly understood form of heart failure, characterized by impaired diastolic function. It is …

" The beginning of wisdom is found in doubting; by doubting we come to question, and by
seeking we may come upon the truth."–Pierre Abélard CD8 is a glycoprotein expressed on …

The origin and specificity of αβ TCR+ T cells that express CD8αα have been controversial
issues. Here we provide direct evidence that precursors of functional CD8αα T cells are …

The gastrointestinal tract is the central organ for uptake of fluids and nutrients, and at the
same time it forms the main protective barrier between the sterile environment of the body …

The small intestine plays a key role in immunity and mediates inflammatory responses to
high fat diets. We have used single-cell RNA-sequencing (scRNA-seq) and statistical …

The intestine is fundamental for the uptake of fluids and nutrients, but it also provides a main
entrance for pathogens. This unique challenge has imposed an important evolutionary drive …

The intestinal intraepithelial lymphocytes (IELs) are mostly T cells dispersed as single cells
within the epithelial cell layer that surrounds the intestinal lumen. IELs are, therefore …

Coreceptor CD4 and CD8αβ double-negative (DN) TCRαβ+ intraepithelial T cells, although
numerous, have been greatly overlooked and their contribution to the immune response is …