Highlights•Similarities and differences in the embryonic origin and differentiation of PrE
(mouse) compared to hypoblast (human) development.•Signficant aspects of signaling …

Cell fate decisions remain poorly understood at the molecular level. Embryogenesis
provides a unique opportunity to analyze molecular details associated with cell fate …

Mammalian pre-implantation development is entirely devoted to the specification of extra-
embryonic lineages, which are fundamental for embryo morphogenesis and support. The …

Abstract Model parameter inference is a universal problem across science. This challenge is
particularly pronounced in developmental biology, where faithful mechanistic descriptions …

The lineage decision that generates the epiblast and primitive endoderm from the inner cell
mass (ICM) is a paradigm for cell fate specification. Recent mathematics has formalized …

Preimplantation development is the only stage of human development that can be studied
outside the body in real time, as human embryos can be produced by in vitro fertilization and …

The hypoblast is an essential extra-embryonic tissue set aside within the inner cell mass
early in mammalian embryo development, in the blastocyst. Research with human embryos …

All emerging life must function while being built. The developing embryo requires an
aqueous environment, a supply of nutrients, gas exchange and waste management …

Rat primitive extraembryonic endoderm (pXEN) stem cell lines indefinitely preserve the
characteristic features of the early extraembryonic endoderm (ExEn) in vitro, but require …

Embryonic stem cells (ESCs) can self-organize in vitro into developmental patterns with
spatial organization and molecular similarity to that of early embryonic stages. This self …