While targeting of proteins synthesized in the cytosol to any organelle is complex,
mitochondria present the most challenging of destinations. First, import of nuclear-encoded …

The proper distribution of proteins between the cytosol and various membrane-bound
compartments is crucial for the functionality of eukaryotic cells. This requires the cooperation …

Intrinsically disordered regions make up a large part of the proteome, but the sequence-to-
function relationship in these regions is poorly understood, in part because the primary …

Most mitochondrial proteins are targeted to the organelle by N-terminal mitochondrial
targeting sequences (MTSs, or “presequences”) that are recognized by the import machinery …

Mitochondrial accumulation of intracellular β-amyloid (Aβ) peptides is present in the brains
of individuals with Alzheimer's disease (AD) as well as in related mouse models of AD. This …

Oligosaccharyltransferase (OST) transfers an oligosaccharide chain to the Asn residue in
the Asn-X-Ser/Thr sequon in proteins, where X is not proline. A sequon was tethered to an …

The presequence translocase TIM23 is a highly dynamic complex in which its subunits can
adopt multiple conformations and undergo association-dissociation to facilitate import of …

The majority of mitochondrial proteins are encoded in the nuclear genome and imported into
mitochondria posttranslationally from the cytosol. An N-terminal presequence functions as …

The function Bax and/or Bak in constituting a gateway for mitochondrial apoptosis in
response to apoptotic stimuli has been unequivocally demonstrated. However, recent work …

Promiscuous recognition of ligands by proteins is as important as strict recognition in
numerous biological processes. In living cells, many short, linear amino acid motifs function …