Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …
embryonic and organ development, as well as cancer progression. Genome-wide …
HMGB1 in health and disease
R Kang, R Chen, Q Zhang, W Hou, S Wu, L Cao… - Molecular aspects of …, 2014 - Elsevier
Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …
emergence of chromosomal instability, development of unscheduled cell death, skewed …
Triple-negative breast cancer in African-American women: disparities versus biology
EC Dietze, C Sistrunk, G Miranda-Carboni… - Nature Reviews …, 2015 - nature.com
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that
disproportionately affects BRCA1 mutation carriers and young women of African origin …
disproportionately affects BRCA1 mutation carriers and young women of African origin …
Multi-omics characterization of the 4T1 murine mammary gland tumor model
Background: Tumor models are critical for our understanding of cancer and the development
of cancer therapeutics. The 4T1 murine mammary cancer cell line is one of the most widely …
of cancer therapeutics. The 4T1 murine mammary cancer cell line is one of the most widely …
Racial disparity and triple-negative breast cancer in African-American women: a multifaceted affair between obesity, biology, and socioeconomic determinants
S Siddharth, D Sharma - Cancers, 2018 - mdpi.com
Triple negative breast cancer (TNBC) is a molecularly heterogeneous disease whose
incidence is disproportionately higher in African American (AA) women compared to …
incidence is disproportionately higher in African American (AA) women compared to …
[HTML][HTML] Interplay between microRNAs and WNT/β-catenin signalling pathway regulates epithelial–mesenchymal transition in cancer
NM Ghahhari, S Babashah - European journal of cancer, 2015 - Elsevier
The WNT/β-catenin signalling implies its significance in maintaining an epithelial cell
phenotype, proper cell–cell junctions, and tissue homeostasis. Dysregulation of the …
phenotype, proper cell–cell junctions, and tissue homeostasis. Dysregulation of the …
[HTML][HTML] Oncological role of HMGA2
S Zhang, Q Mo, X Wang - International journal of …, 2019 - spandidos-publications.com
The high mobility group A2 (HMGA2) protein is a non‑histone architectural transcription
factor that modulates the transcription of several genes by binding to AT‑rich sequences in …
factor that modulates the transcription of several genes by binding to AT‑rich sequences in …
β-Catenin is required for the tumorigenic behavior of triple-negative breast cancer cells
J Xu, JR Prosperi, N Choudhury, OI Olopade, KH Goss - PloS one, 2015 - journals.plos.org
Our previous data illustrated that activation of the canonical Wnt signaling pathway was
enriched in triple-negative breast cancer and associated with reduced overall survival in all …
enriched in triple-negative breast cancer and associated with reduced overall survival in all …
CBP/p300: critical co-activators for nuclear steroid hormone receptors and emerging therapeutic targets in prostate and breast cancers
Simple Summary The CREB-binding protein (CBP) and p300 are paralogous lysine
acetyltransferases that serve as critical co-activators for transcription factors involved in …
acetyltransferases that serve as critical co-activators for transcription factors involved in …
ETMR: a tumor entity in its infancy
Abstract Embryonal tumor with Multilayered Rosettes (ETMR) is a relatively rare but typically
deadly type of brain tumor that occurs mostly in infants. Since the discovery of the …
deadly type of brain tumor that occurs mostly in infants. Since the discovery of the …