Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in
diverse biological processes including tissue repair, adipogenesis, immune cell …

Galectins play relevant roles in tumor development, progression and metastasis.
Accordingly, galectins are certainly enticing targets for medical intervention in cancer. To …

FGF/FGFR signaling is critical for the development and homeostasis of the human body and
imbalanced FGF/FGFR contributes to the progression of severe diseases, including cancers …

Galectins (Gals), a family of multifunctional glycan-binding proteins, have been traditionally
defined as β-galactoside binding lectins. However, certain members of this family have …

Galectins are among organisms' most abundantly expressed lectins (carbohydrate‐binding
proteins) that specifically bind β‐galactosides. They act not only outside the cell, where they …

We have obtained the X-ray crystal structure of the galectin-8 N-terminal domain (galectin-
8N) with a previously reported quinoline–galactoside ligand at a resolution of 1.6 Å. Based …

Numerous articles have reported the involvement of linker in regulating bioactivity of tandem-
repeat galectins. We hypothesize that linker interacts with N/C-CRDs to regulate the …

Galectin-8 is a small soluble lectin with two carbohydrate recognition domains (CRDs). N-
and C-terminal CRDs of Gal-8 differ in their specificity for glycan ligands. Here, we wanted to …

The mechanisms underlying the cellular response to extracellular matrices (ECMs) that
consist of multiple adhesive ligands are still poorly understood. Here, we address this topic …

Galectins are a family of carbohydrate-binding proteins found in vertebrates in great
abundance and diversity in terms of both structure and ligand-binding properties as well as …