Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy

S Biswas, CM Rao - European journal of pharmacology, 2018 - Elsevier
Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

The environment and schizophrenia

J Van Os, G Kenis, BPF Rutten - Nature, 2010 - nature.com
Psychotic syndromes can be understood as disorders of adaptation to social context.
Although heritability is often emphasized, onset is associated with environmental factors …

Research Domain Criteria: cognitive systems, neural circuits, and dimensions of behavior

SE Morris, BN Cuthbert - Dialogues in clinical neuroscience, 2012 - Taylor & Francis
Current diagnostic systems for mental disorders were established before the tools of
neuroscience were available, and although they have improved the reliability of psychiatric …

Resilience in mental health: linking psychological and neurobiological perspectives

BPF Rutten, C Hammels, N Geschwind… - Acta Psychiatrica …, 2013 - Wiley Online Library
Objective To review the literature on psychological and biological findings on resilience (ie
the successful adaptation and swift recovery after experiencing life adversities) at the level of …

Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings

L Smigielski, V Jagannath, W Rössler, S Walitza… - Molecular …, 2020 - nature.com
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …

Can bipolar disorder be viewed as a multi-system inflammatory disease?

M Leboyer, I Soreca, J Scott, M Frye, C Henry… - Journal of affective …, 2012 - Elsevier
BACKGROUND: Patients with bipolar disorder are known to be at high risk of premature
death. Comorbid cardio-vascular diseases are a leading cause of excess mortality, well …

Developmental origins of disruptive behaviour problems: the 'original sin'hypothesis, epigenetics and their consequences for prevention

RE Tremblay - Journal of child psychology and psychiatry, 2010 - Wiley Online Library
This paper reviews publications on developmental trajectories of disruptive behaviour (DB)
problems (aggression, opposition‐defiance, rule breaking, and stealing‐vandalism) over the …

[图书][B] The developing genome: An introduction to behavioral epigenetics

DS Moore - 2015 - books.google.com
Why do we grow up to look, act, and feel as we do? Through most of the twentieth century,
scientists and laypeople answered this question by referring to two factors alone: our …

Epigenetic modifications in schizophrenia and related disorders: molecular scars of environmental exposures and source of phenotypic variability

J Richetto, U Meyer - Biological Psychiatry, 2021 - Elsevier
Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …

DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression

M Fuchikami, S Morinobu, M Segawa, Y Okamoto… - PloS one, 2011 - journals.plos.org
Major depression, because of its recurring and life-threatening nature, is one of the top 10
diseases for global disease burden. Major depression is still diagnosed on the basis of …