The actions of cannabis are mediated by receptors that are part of an endogenous
cannabinoid system. The endocannabinoid system (ECS) consists of the naturally occurring …

The human gut is a composite anaerobic environment with a large, diverse and dynamic
enteric microbiota, represented by more than 100 trillion microorganisms, including at least …

The endocannabinoid system (ECS) is involved in various processes, including brain
plasticity, learning and memory, neuronal development, nociception, inflammation, appetite …

The management of visceral pain in patients with disorders of gut–brain interaction, notably
irritable bowel syndrome, presents a considerable clinical challenge, with few available …

Background In ancient medicine, extracts of the marijuana plant Cannabis sativa were used
against diseases of the gastrointestinal (GI) tract. Today, our knowledge of the ingredients of …

Background Intestinal immune activation is involved in irritable bowel syndrome (IBS)
pathophysiology. While most dietary approaches in IBS involve food avoidance, there are …

Results Mean BDI score was higher in IBS group than in controls. IBS-QOL score was
significantly lower in IBS patients compared to the control group, in all IBS-QOL domains …

Visceral pain is generally poorly localized and characterized by hypersensitivity to a
stimulus such as organ distension. In concert with chronic visceral pain, there is a high …

The endocannabinoid system mainly consists of endogenously produced cannabinoids
(endocannabinoids) and two G protein-coupled receptors (GPCRs), cannabinoid receptors …

The endocannabinoid system is a metabolic pathway involved in the communication
between the gut microbiota and the host. In the gut, the endocannabinoid system regulates …