RNA-binding proteins in bacteria

E Holmqvist, J Vogel - Nature Reviews Microbiology, 2018 - nature.com
RNA-binding proteins (RBPs) are central to most if not all cellular processes, dictating the
fate of virtually all RNA molecules in the cell. Starting with pioneering work on ribosomal …

Bacterial small RNA regulators: versatile roles and rapidly evolving variations

S Gottesman, G Storz - Cold Spring Harbor perspectives …, 2011 - cshperspectives.cshlp.org
Small RNA regulators (sRNAs) have been identified in a wide range of bacteria and found to
play critical regulatory roles in many processes. The major families of sRNAs include true …

Regulation of bacterial virulence by Csr (Rsm) systems

CA Vakulskas, AH Potts, P Babitzke… - Microbiology and …, 2015 - Am Soc Microbiol
Most bacterial pathogens have the remarkable ability to flourish in the external environment
and in specialized host niches. This ability requires their metabolism, physiology, and …

Gac/Rsm signal transduction pathway of γ‐proteobacteria: from RNA recognition to regulation of social behaviour

K Lapouge, M Schubert, FHT Allain… - Molecular …, 2008 - Wiley Online Library
In many γ‐proteobacteria, the conserved GacS/GacA (BarA/UvrY) two‐component system
positively controls the expression of one to five genes specifying small RNAs (sRNAs) that …

Global regulation by CsrA and its RNA antagonists

T Romeo, P Babitzke - Microbiology spectrum, 2018 - Am Soc Microbiol
The sequence-specific RNA binding protein CsrA is employed by diverse bacteria in the
posttranscriptional regulation of gene expression. Its binding interactions with RNA have …

Structure of Escherichia coli Hfq bound to polyriboadenylate RNA

TM Link, P Valentin-Hansen… - Proceedings of the …, 2009 - National Acad Sciences
Hfq is a small, highly abundant hexameric protein that is found in many bacteria and plays a
critical role in mRNA expression and RNA stability. As an “RNA chaperone,” Hfq binds AU …

Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA

A Brencic, S Lory - Molecular microbiology, 2009 - Wiley Online Library
One of the prokaryotic post‐transcriptional regulatory mechanisms involves the CsrA/RsmA
family of proteins that act by modulating translation initiation at target mRNAs. In this study …

Pseudomonas aeruginosa biofilm matrix polysaccharide Psl is regulated transcriptionally by RpoS and post‐transcriptionally by RsmA

Y Irie, M Starkey, AN Edwards, DJ Wozniak… - Molecular …, 2010 - Wiley Online Library
Extracellular polysaccharides are important components of biofilms. In non‐mucoid
Pseudomonas aeruginosa strains, the Pel and Psl polysaccharides are major structural …

Post‐transcriptional regulation on a global scale: form and function of Csr/Rsm systems

T Romeo, CA Vakulskas… - Environmental …, 2013 - Wiley Online Library
Originally described as a repressor of gene expression in the stationary phase of growth,
CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation …

Structural basis of the non-coding RNA RsmZ acting as a protein sponge

O Duss, E Michel, M Yulikov, M Schubert, G Jeschke… - Nature, 2014 - nature.com
MicroRNA and protein sequestration by non-coding RNAs (ncRNAs) has recently generated
much interest. In the bacterial Csr/Rsm system, which is considered to be the most general …