Self‐healing biomaterials: from molecular concepts to clinical applications

M Diba, S Spaans, K Ning, BD Ippel… - Advanced Materials …, 2018 - Wiley Online Library
Biomaterials are being applied in increasingly complex areas such as tissue engineering,
bioprinting, and regenerative medicine. For these applications, challenging—or even …

Atomic force microscopy of virus shells

PJ de Pablo - Seminars in cell & developmental biology, 2018 - Elsevier
Microscopes are used to characterize small specimens with the help of probes, such as
photons and electrons in optical and electron microscopies, respectively. In atomic force …

Monitoring SARS-CoV-2 surrogate TGEV individual virions structure survival under harsh physicochemical environments

M Cantero, D Carlero, FJ Chichón, J Martín-Benito… - Cells, 2022 - mdpi.com
Effective airborne transmission of coronaviruses via liquid microdroplets requires a virion
structure that must withstand harsh environmental conditions. Due to the demanding …

Symmetry disruption commits vault particles to disassembly

P Guerra, M González-Alamos, A Llauró… - Science …, 2022 - science.org
Vaults are ubiquitous ribonucleoprotein particles involved in a diversity of cellular
processes, with promising applications as nanodevices for delivery of multiple cargos. The …

Cementing proteins provide extra mechanical stabilization to viral cages

M Hernando-Pérez, S Lambert… - Nature …, 2014 - nature.com
The study of virus shell stability is key not only for gaining insights into viral biological cycles
but also for using viral capsids in materials science. The strength of viral particles depends …

Inferring mechanical properties of the SARS-CoV-2 virus particle with nano-indentation tests and numerical simulations

A Nonn, B Kiss, W Pezeshkian… - Journal of the …, 2023 - Elsevier
The pandemic caused by the SARS-CoV-2 virus has claimed more than 6.5 million lives
worldwide. This global challenge has led to accelerated development of highly effective …

Cargo–shell and cargo–cargo couplings govern the mechanics of artificially loaded virus-derived cages

A Llauró, D Luque, E Edwards, BL Trus, J Avera… - Nanoscale, 2016 - pubs.rsc.org
Nucleic acids are the natural cargo of viruses and key determinants that affect viral shell
stability. In some cases the genome structurally reinforces the shell, whereas in others …

Mechanical tomography of an archaeal lemon-shaped virus reveals membrane-like fluidity of the capsid and liquid nucleoprotein cargo

M Cantero, V Cvirkaite-Krupovic… - Proceedings of the …, 2023 - National Acad Sciences
Archaeal lemon-shaped viruses have unique helical capsids composed of highly
hydrophobic protein strands which can slide past each other resulting in remarkable …

Latest advances in the development of eukaryotic vaults as targeted drug delivery systems

A Muñoz-Juan, A Carreño, R Mendoza, JL Corchero - Pharmaceutics, 2019 - mdpi.com
The use of smart drug delivery systems (DDSs) is one of the most promising approaches to
overcome some of the drawbacks of drug-based therapies, such as improper biodistribution …

Electromechanical Photophysics of GFP Packed Inside Viral Protein Cages Probed by Force‐Fluorescence Hybrid Single‐Molecule Microscopy

K Strobl, E Selivanovitch, P Ibáñez‐Freire… - Small, 2022 - Wiley Online Library
Packing biomolecules inside virus capsids has opened new avenues for the study of
molecular function in confined environments. These systems not only mimic the highly …