T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …

Programmed cell death protein 1 (PD-1) ligation delimits immunogenic responses in T cells.
However, the consequences of programmed cell death 1 ligand 1 (PD-L1) ligation in T cells …

Signal transducer and activator of transcription (STAT) 3 is one of the most complex
regulators of transcription. Constitutive activation of STAT3 has been reported in many types …

Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …

CD4+ T cells are crucial in achieving a regulated effective immune response to pathogens.
Naive CD4+ T cells are activated after interaction with antigen‐MHC complex and …

Th17 cell differentiation and pathogenicity depend on metabolic reprogramming inducing
shifts toward glycolysis. Here, we show that the pyruvate kinase M2 (PKM2), a glycolytic …

The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …

In this review, we describe the role of suppressor of cytokine signaling-3 (SOCS3) in
modulating the outcome of infections and autoimmune diseases as well as the underlying …