Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Lesihmaniasis is one of the major neglected tropical disease caused by the parasite of the
genus Leishmania. The disease has more than one clinical forms and the visceral form is …

A molecular docking analysis has been carried out to examine potential Leishmania protein
targets of antiprotozoal plant-derived polyphenolic compounds. A total of 352 phenolic …

Background NME1 has been exploited as a potential translational target for decades.
Substantial efforts have been made to upregulate the expression of NME1 and restore its …

Nucleoside diphosphate kinases (NDPK) are oligomeric proteins involved in the synthesis of
nucleoside triphosphates. Their tridimensional structure has been solved by X-ray …

Neglected Tropical Diseases (NTDs), like leishmaniasis, are major causes of mortality in
resource-limited countries. The mortality associated with these diseases is largely due to …

The fundamental biological function of nucleoside diphosphate kinase (NDK) is to catalyze
the reversible exchange of the γ-phosphate between nucleoside triphosphate (NTP) and …

Malaria, leishmaniasis, Chagas disease, and human African trypanosomiasis continue to
cause considerable suffering and death in developing countries. Current treatment options …

Trypanosoma cruzi is the causative agent of Chagas' disease, an endemic and neglected
disease. The treatment is limited to only two drugs, benznidazole (BZL) and nifurtimox …

Abstract Filamentous Fungal Human Pathogens (FFHPs) such as Aspergillus fumigatus, are
growing resistant to currently available antifungal drugs. One possible target, the Nucleoside …