Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases

A Bigi, R Cascella, F Chiti, C Cecchi - Bioessays, 2022 - Wiley Online Library
Amyloid fibril formation plays a central role in the pathogenesis of a number of
neurodegenerative diseases, including Alzheimer and Parkinson diseases. Transient …

[HTML][HTML] Raman Spectroscopy Techniques for the Investigation and Diagnosis of Alzheimer's Disease

P Polykretis, M Banchelli, C D'Andrea… - Frontiers in Bioscience …, 2022 - imrpress.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder, resulting in
memory loss, cognitive decline, bodily function impairment, and finally death. The growing …

Impact of seed amplification assay and surface-enhanced Raman spectroscopy combined approach on the clinical diagnosis of Alzheimer's disease

C D'Andrea, FA Cazzaniga, E Bistaffa… - Translational …, 2023 - Springer
Background The current diagnosis of Alzheimer's disease (AD) is based on a series of
analyses which involve clinical, instrumental and laboratory findings. However, signs …

Label-free SERS detection of proteins based on machine learning classification of chemo-structural determinants

A Barucci, C D'Andrea, E Farnesi, M Banchelli… - Analyst, 2021 - pubs.rsc.org
Establishing standardized methods for a consistent analysis of spectral data remains a
largely underexplored aspect in surface-enhanced Raman spectroscopy (SERS) …

Aβ oligomers dysregulate calcium homeostasis by mechanosensitive activation of AMPA and NMDA receptors

G Fani, B Mannini, G Vecchi, R Cascella… - ACS Chemical …, 2021 - ACS Publications
Alzheimer's disease, which is the most common form of dementia, is characterized by the
aggregation of the amyloid β peptide (Aβ) and by an impairment of calcium homeostasis …

[HTML][HTML] Rapid determination of phenolic composition in chamomile (Matricaria recutita L.) using surface-enhanced Raman spectroscopy

M de Angelis, C Amicucci, M Banchelli, C D'Andrea… - Food Chemistry, 2025 - Elsevier
Flavonoids and hydroxycinnamic acids are the main responsible of the antioxidant activity of
chamomile (Matricaria recutita L.). Traditional methods for the analysis of the phenolic …

Copper trafficking system in cells: insights into coordination chemistry and toxicity

J Han - Dalton Transactions, 2023 - pubs.rsc.org
Transition metal ions, such as copper, are indispensable components in the biological
system. Copper ions which primarily exist in two major oxidation states Cu (I) and Cu (II) play …

A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer's disease CSF

A Bigi, L Napolitano, DM Vadukul, F Chiti… - Alzheimer's Research & …, 2024 - Springer
Background Amyloid-β42 (Aβ42) aggregation consists of a complex chain of nucleation
events producing soluble oligomeric intermediates, which are considered the major …

Applications of Raman spectroscopy in clinical medicine

Y Qi, EX Chen, D Hu, Y Yang, Z Wu, M Zheng… - Food …, 2024 - Wiley Online Library
Raman spectroscopy is a nondestructive and highly effective technique for analyzing
biological tissues and diagnosing diseases by providing detailed spectral information about …

Molecular beacon decorated silver nanowires for quantitative miRNA detection by a SERS approach

M Banchelli, S Tombelli, M de Angelis, C D'Andrea… - Analytical …, 2023 - pubs.rsc.org
Advantages of biosensors based on surface enhanced Raman scattering (SERS) rely on
improved sensitivity and specificity, and suited reproducibility in detecting a target molecule …