Nuclear magnetic resonance spectroscopy in clinical metabolomics and personalized medicine: current challenges and perspectives

MPM Letertre, P Giraudeau, P De Tullio - Frontiers in Molecular …, 2021 - frontiersin.org
Personalized medicine is probably the most promising area being developed in modern
medicine. This approach attempts to optimize the therapies and the patient care based on …

Combined nuclear magnetic resonance spectroscopy and mass spectrometry approaches for metabolomics

MPM Letertre, G Dervilly, P Giraudeau - Analytical chemistry, 2020 - ACS Publications
Metabolomics is based on cutting-edge analytical methods that provide a “snapshot” of all
the detectable metabolites, small molecules generally weighing under 1200 Da, present in …

NMR: unique strengths that enhance modern metabolomics research

AS Edison, M Colonna, GJ Gouveia… - Analytical …, 2020 - ACS Publications
Nuclear magnetic resonance (NMR) spectroscopy is an important analytical technique in
metabolomics. Because it provides atomic-level detail of small molecules, NMR is …

Early breast cancer detection using untargeted and targeted metabolomics

Y Wei, P Jasbi, X Shi, C Turner, J Hrovat… - Journal of proteome …, 2021 - ACS Publications
Breast cancer (BC) is a common cause of morbidity and mortality, particularly in women.
Moreover, the discovery of diagnostic biomarkers for early BC remains a challenging task …

Integrated analysis of colorectal cancer reveals cross-cohort gut microbial signatures and associated serum metabolites

R Gao, C Wu, Y Zhu, C Kong, Y Zhu, Y Gao, X Zhang… - Gastroenterology, 2022 - Elsevier
Background & Aims Studies have reported abnormal gut microbiota or circulating
metabolome associated with colorectal cancer (CRC), but it remains a challenge to capture …

Recent advances in NMR-based metabolomics

GA Nagana Gowda, D Raftery - Analytical Chemistry, 2017 - ACS Publications
NMR spectroscopy, one of the two major analytical platforms utilized in the metabolomics
field, has witnessed a large number of advances in fundamental studies, methods …

A new hybrid filter/wrapper algorithm for feature selection in classification

J Zhang, Y Xiong, S Min - Analytica chimica acta, 2019 - Elsevier
Feature selection can greatly enhance the performance of a learning algorithm when
dealing with a high dimensional data set. The filter method and the wrapper method are the …

NMR-based metabolomics and fluxomics: developments and future prospects

P Giraudeau - Analyst, 2020 - pubs.rsc.org
NMR spectroscopy is an essential analytical technique in metabolomics and fluxomics
workflows, owing to its high structural elucidation capabilities combined with its intrinsic …

Metabolomics and lipidomics of ischemic stroke

A Au - Advances in clinical chemistry, 2018 - Elsevier
Ischemic stroke is a sudden loss of brain function due to the reduction of blood flow. Brain
tissues cease to function with subsequent activation of the ischemic cascade. Metabolomics …

Emerging applications of metabolomics in clinical pharmacology

H Pang, W Jia, Z Hu - Clinical Pharmacology & Therapeutics, 2019 - Wiley Online Library
Metabolic disturbances have been associated with many human diseases, including cancer,
diabetes, and cardiovascular disease. Metabolomics, a rapidly growing member of the …