Accumulating evidence indicates that gut transit time is a key factor in shaping the gut
microbiota composition and activity, which are linked to human health. Both population-wide …

The act of defaecation, although a ubiquitous human experience, requires the coordinated
actions of the anorectum and colon, pelvic floor musculature, and the enteric, peripheral and …

Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local
diseases, direct access to unique therapeutic targets and the potential for increasing …

Introduction: Physiological pH and chemical pKa are two sides of the same coin in defining
the ionization of a drug in the human body. The Henderson-Hasselbalch equation and pH …

The main objective of this review is to discuss recent advancements in the overall
investigation and in vivo prediction of drug absorption. The intestinal permeability of an …

Little is known about how colonic transit time relates to human colonic metabolism and its
importance for host health, although a firm stool consistency, a proxy for a long colonic …

In recent decades, many efforts have been made in order to improve drug bioavailability
after oral administration. Gastroretentive drug delivery systems are a good example; they …

In recent years, many attempts have been made to enhance the drug bioavailability and
therapeutic effectiveness of oral dosage forms. In this context, various gastroretentive drug …

Growing evidence suggests the importance of the small intestinal bacteria in the diet–host–
microbiota dialogue in various facets of health and disease. Yet, this body site is still poorly …

Disturbances of gastric, intestinal and colonic motor and sensory functions affect a large
proportion of the population worldwide, impair quality of life and cause considerable health …