BACKGROUND Ovarian follicles undergo dynamic morphologic and endocrinologic
changes during the human menstrual cycle. The physiologic mechanisms underlying …

To allow selection of embryos for transfer after in vitro fertilization, ovarian stimulation is
usually carried out with exogenous gonadotropins. To compensate for changes induced by …

In a randomized multicenter study, the efficacies of two different GnRH agonists were
compared with that of hCG for triggering final stages of oocyte maturation after ovarian …

Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating
ovulation in sexually mature females via the central control of the hypothalamic–pituitary …

The first edition of the Textbook of Assisted Reproductive Techniques was published in
2001. As the textbook now enters its sixth edition, some 45 years since the birth of Louise …

Context: For the last 40 yr, the first line of treatment for anovulation in infertile women has
been clomiphene citrate (CC). CC is a safe, effective oral agent but is known to have …

Epigenetic reprogramming plays a pivotal role during embryogenesis, including both
covalent and non-covalent modifications to chromatin. In this study, we investigated the role …

Luteinizing hormone (LH) in synergy with follicle stimulating hormone (FSH) stimulates
normal follicular growth and ovulation. FSH is frequently used in assisted reproductive …

The use of assisted reproductive technologies (ART) has been increasing 13 over the past
three decades and in developed countries, ART accounts for 1-14 3% of annual births. In an …

In the gonadotrophin-dependent stage of follicular development, FSH-and LH-signalling
pathways play an obligatory role in follicle differentiation, selection and survival. Under the …