Disintegration is the de-aggregation of particles within tablets upon exposure to aqueous
fluids. Being an essential step in the bioavailability cascade, disintegration is a fundamental …

Functional-related characteristics (FRCs) are properties of excipients that can potentially
influence one or more functions of that excipient in the final product. Knowledge of FRCs is …

Background/Objectives: Hydroxypropyl methylcellulose (HPMC) is one of the most
commonly used hydrophilic polymers in formulations of matrix tablets for controlled release …

The stability of pharmaceuticals is an important product quality attribute. Of the known factors
affecting stability, moisture is often perceived as the most common cause of drug …

The application of time-domain NMR (TD-NMR) analysis to quantify water content in
pharmaceutical ingredients is demonstrated. The initial phase of the study employed a …

This study applied partial least squares (PLS) regression to nuclear magnetic resonance
(NMR) relaxation curves to quantify the free base of an active pharmaceutical ingredient …

Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging has been used to study
the hydrolysis of tenofovir disoproxil fumarate (TDF) to tenofovir monosoproxil (TM) within an …

Excipients are ubiquitous in pharmaceutical products, and often, they can also play a critical
role in maintaining product quality. For a product containing a moisture-sensitive drug …

Hardness is a critical quality characteristic of pharmaceutical oral jelly. In this study, the
hardness was determined by using the T 2 relaxation curves measured by time-domain …

The complex physical properties of natural plant products (NPPs) greatly influence the
disintegration of NPP tablets, and the evaluation of their disintegration properties is …